Title: Fasting, Autophagy, and mTOR Inhibition


  • The only two interventions that really seem to offer longevity benefits are rapamycin supplementation and some degree of fasting
    • They both suppress mTOR (mechanistic target of rapamycin) and in turn increase autophagy
      • Autophagy is the process by which cells eat themselves – the dysfunctional cells (like cancer cells) tend to be “eaten” first
    • It’s currently impossible to measure the level of autophagy taking place in the body
    • Fasting
      • Fasting is the single most potent tool in our toolbox of nutrition
      • Peter estimates that around day 3 of a prolonged water-only fast autophagy starts taking place
      • The fasting function:
        • F (x,y,z) (AKA fasting is a function of x, y, and z)
          • x = the amount you restrict calories (100% = full calorie restriction)
          • y = the duration of the fast
          • z = the frequency at which the fast is repeated
        • For example, Peter does a 7-day fast once per quarter = F (100%, 7 days, 90 days)
      • There are TONS of different fasting regimens
        • But because we can’t measure autophagy – “Anyone who says theirs is the best is either delusional or incapably of understand combinatorial mathematics”
      • During his prolonged fasts, Peter tries to lift as heavy as possible every day (to stimulate mTOR in the muscle – to prevent muscle loss)
    • What does/doesn’t break a fast largely depends on the reason you’re fasting in the first place
      • If the purpose of your fast is caloric restriction and weight loss:
        • Coffee and even eating celery wouldn’t technically break it
      • If the purpose of your fast is gut rest:
        • Coffee breaks the fast
      • If the purpose of your fast is to increase autophagy:
        • We don’t know if something like coffee would break the fast (since we can’t measure autophagy)
      • Oral NR (nicotinamide riboside) (it’s a NAD+ precursor) supplementation and intravenous NAD+ administration are both probably useless
      • “If there was one disease state that seems to benefit more from a ketogenic diet than any of the others it’s type 2 diabetes”



Lets figure it out!  The Fasting Motivation podcast is not medical advice.


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